This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling
via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although …

Brain function critically relies on blood vessels to supply oxygen and nutrients, to establish a
barrier for neurotoxic substances, and to clear waste products. The archetypal vascular …

Neuropathy will afflict over half of the estimated 460 million people worldwide who have
diabetes, 303 of whom approximately onethird will also develop neuropathic pain. 2 The …

Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Purpose: The purpose of this study was to study the status and association among tear-
soluble factors, corneal dendritic cell density, vitamin D, and signs and symptoms in dry eye …

More than 95% of genes in the human genome are alternatively spliced to form multiple
transcripts, often encoding proteins with differing or opposing function. The control of …

Diabetic neuropathy (DN) encompasses a group of clinical or subclinical manifestations
involving a dysfunction in the peripheral nervous system. The cause of the dysfunction is the …

Previous studies on the mechanisms of peripheral nerve injury (PNI) have mainly focused
on the pathophysiological changes within a single injury site. However, recent studies have …

Neuropathic pain is a type of chronic pain caused by injury or dysfunction of the nervous
system, without effective therapeutic approaches. Mesenchymal stromal cells (MSCs) …