Modulation of cellular processes by histone and non-histone protein acetylation
M Shvedunova, A Akhtar - Nature reviews Molecular cell biology, 2022 - nature.com
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
NAD+ metabolism and its roles in cellular processes during ageing
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme for redox reactions, making it
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
central to energy metabolism. NAD+ is also an essential cofactor for non-redox NAD+ …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
[HTML][HTML] BI 456906: discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy
T Zimmermann, L Thomas, T Baader-Pagler… - Molecular …, 2022 - Elsevier
Objective Obesity and its associated comorbidities represent a global health challenge with
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …
a need for well-tolerated, effective, and mechanistically diverse pharmaceutical …
Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts
High-grade serous carcinoma has a poor prognosis, owing primarily to its early
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …
dissemination throughout the abdominal cavity. Genomic and proteomic approaches have …
NAD+ Metabolism in Cardiac Health, Aging, and Disease
Nicotinamide adenine dinucleotide (NAD+) is a central metabolite involved in energy and
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
redox homeostasis as well as in DNA repair and protein deacetylation reactions …
Nicotinamide for the treatment of heart failure with preserved ejection fraction
M Abdellatif, V Trummer-Herbst, F Koser… - Science translational …, 2021 - science.org
Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable
form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we …
form of cardiac decompensation commonly associated with diastolic dysfunction. Here, we …
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
MS Bonkowski, DA Sinclair - Nature reviews Molecular cell biology, 2016 - nature.com
Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …
dependent deacylases with remarkable abilities to prevent diseases and even reverse …
[HTML][HTML] Metabolic control of longevity
Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we
determine the time and dose-dependent effects of NR on blood NAD+ metabolism in …
determine the time and dose-dependent effects of NR on blood NAD+ metabolism in …