Evolutionary constraint and innovation across hundreds of placental mammals
Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …
Graph neural networks: foundation, frontiers and applications
The field of graph neural networks (GNNs) has seen rapid and incredible strides over the
recent years. Graph neural networks, also known as deep learning on graphs, graph …
recent years. Graph neural networks, also known as deep learning on graphs, graph …
Building a knowledge graph to enable precision medicine
Developing personalized diagnostic strategies and targeted treatments requires a deep
understanding of disease biology and the ability to dissect the relationship between …
understanding of disease biology and the ability to dissect the relationship between …
Expasy, the Swiss Bioinformatics Resource Portal, as designed by its users
Abstract The SIB Swiss Institute of Bioinformatics (https://www. sib. swiss) creates, maintains
and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and …
and disseminates a portfolio of reliable and state-of-the-art bioinformatics services and …
AnimalTFDB 4.0: a comprehensive animal transcription factor database updated with variation and expression annotations
WK Shen, SY Chen, ZQ Gan, YZ Zhang… - Nucleic acids …, 2023 - academic.oup.com
Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate
gene expression and play crucial roles in all kinds of biological processes. To keep up with …
gene expression and play crucial roles in all kinds of biological processes. To keep up with …
[HTML][HTML] The biology of vasopressin
S Sparapani, C Millet-Boureima, J Oliver, K Mu… - Biomedicines, 2021 - mdpi.com
Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin
functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for …
functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for …
JGI Plant Gene Atlas: an updateable transcriptome resource to improve functional gene descriptions across the plant kingdom
Gene functional descriptions offer a crucial line of evidence for candidate genes underlying
trait variation. Conversely, plant responses to environmental cues represent important …
trait variation. Conversely, plant responses to environmental cues represent important …
[HTML][HTML] IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor …
M Duan, H Liu, S Xu, Z Yang, F Zhang, G Wang… - Genes & diseases, 2024 - Elsevier
Abstract m 6 A methylation is the most frequent modification of mRNA in eukaryotes and
plays a crucial role in cancer progression by regulating biological functions. Insulin-like …
plays a crucial role in cancer progression by regulating biological functions. Insulin-like …
The Monarch Initiative in 2024: an analytic platform integrating phenotypes, genes and diseases across species
TE Putman, K Schaper, N Matentzoglu… - Nucleic acids …, 2024 - academic.oup.com
Bridging the gap between genetic variations, environmental determinants, and phenotypic
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …
The scalable precision medicine open knowledge engine (SPOKE): a massive knowledge graph of biomedical information
Abstract Motivation Knowledge graphs (KGs) are being adopted in industry, commerce and
academia. Biomedical KG presents a challenge due to the complexity, size and …
academia. Biomedical KG presents a challenge due to the complexity, size and …