Translation elongation is a key step of protein synthesis, during which the nascent
polypeptide chain extends by one amino acid residue during one elongation cycle. More …

The accurate synthesis of proteins, dictated by the corresponding nucleotide sequence
encoded in mRNA, is essential for cell growth and survival. Central to this process are the …

Some animals have the remarkable capacity to acclimate across generations to projected
future climate change,,,; however, the underlying molecular processes are unknown. We …

Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV), is a highly
threatening disease with no specific treatment. Fortunately, the development of vaccines has …

The 26 S proteasome is a large proteolytic machine, which degrades most intracellular
proteins. We found that thioredoxin, Txnl1/TRP32, binds to Rpn11, a subunit of the …

The eEF1 family of mammalian translation elongation factors is comprised of the two
variants of eEF1A (eEF1A1 and eEF1A2), and the eEF1B complex. The latter consists of …

In their natural environments, cells are regularly exposed to oxidizing conditions that may
lead to protein misfolding. If such misfolded proteins are allowed to linger, they may form …

Heterozygous de novo variants in the eukaryotic elongation factor EEF1A2 have previously
been described in association with intellectual disability and epilepsy but never functionally …

Aims In our previous study, eEF 1A1 was identified to be a new target for protecting brain
ischemia injury, but the mechanism remains largely unknown. In this study, we screened the …

Phosphoproteomics is often aimed at deciphering the modified components of signaling
pathways in certain organisms, tissues and pathologies. Phosphorylation of housekeeping …