Hereditary cancer predisposition syndromes
JE Garber, K Offit - Journal of clinical oncology, 2005 - ascopubs.org
Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …
BRCA1 and BRCA2 and the genetics of breast and ovarian cancer
PL Welcsh, MC King - Human molecular genetics, 2001 - academic.oup.com
Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose
individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 …
individuals to breast and ovarian cancers. Progress in determining the function of BRCA1 …
Frequencies of BRCA1 and BRCA2 mutations among 1,342 unselected patients with invasive ovarian cancer
S Zhang, R Royer, S Li, JR McLaughlin, B Rosen… - Gynecologic …, 2011 - Elsevier
BACKGROUND: The heritable fraction of ovarian cancer exceeds that of any other common
adult cancer. Most inherited cases of ovarian cancer are due to a germline mutation in …
adult cancer. Most inherited cases of ovarian cancer are due to a germline mutation in …
BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases
T Pal, J Permuth‐Wey, JA Betts… - … Journal of the …, 2005 - Wiley Online Library
BACKGROUND It is believed that BRCA1 and BRCA2 germline mutations account for the
majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are …
majority of hereditary ovarian carcinomas; however, to the authors' knowledge, there are …
Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin–cohort study in Ontario, Canada
Background: BRCA1 and BRCA2 mutations in general populations and in various types of
cancers have not been well characterized. We investigated the presence of these mutations …
cancers have not been well characterized. We investigated the presence of these mutations …
Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
A population-based series of 649 unselected incident cases of ovarian cancer diagnosed in
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …
Ontario, Canada, during 1995–96 was screened for germline mutations in BRCA1 and …
Clinical Characteristics of Individuals With Germline Mutations in BRCA1 and BRCA2: Analysis of 10,000 Individuals
TS Frank, AM Deffenbaugh, JE Reid… - Journal of Clinical …, 2002 - ascopubs.org
PURPOSE: To assess the characteristics that correlate best with the presence of mutations
in BRCA1 and BRCA2 in individuals tested in a clinical setting. PATIENTS AND METHODS …
in BRCA1 and BRCA2 in individuals tested in a clinical setting. PATIENTS AND METHODS …
Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers
LC Hartmann, TA Sellers, DJ Schaid… - Journal of the …, 2001 - academic.oup.com
Background: In women with a family history of breast cancer, bilateral prophylactic
mastectomy is associated with a decreased risk of subsequent breast cancer of …
mastectomy is associated with a decreased risk of subsequent breast cancer of …
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer
ContextGenetic testing for inherited mutations in BRCA1 and BRCA2 has become integral to
the care of women with a severe family history of breast or ovarian cancer, but an unknown …
the care of women with a severe family history of breast or ovarian cancer, but an unknown …
Risk-reducing salpingo-oophorectomy for the prevention of BRCA1-and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study
Purpose Risk-reducing salpingo-oophorectomy (RRSO) has been widely adopted as a key
component of breast and gynecologic cancer risk-reduction for women with BRCA1 and …
component of breast and gynecologic cancer risk-reduction for women with BRCA1 and …