Localized or topical administration of drugs may be considered as a potential approach for
overcoming the problems caused by the various biological barriers encountered in drug …

Background Pain is a vital sense that indicates the risk of injury at a particular body part.
Successful control of pain is the principal aspect in medical treatment. In recent years, the …

In dental practice, local anesthesia causes pain, fear, and stress, and is frequently the
reason that patients abandon treatment. Topical anesthetics are applied in order to minimize …

The combination of pharmaceutical technologies can be a wise choice for developing
innovative therapeutic strategies. The association of nanocarriers and gels provides new …

The rationale of this study was to formulate topically effective sustained release ophthalmic
Methazolamide (MTA) liposomal in-situ gel. Lipid film hydration method was employed for …

Introduction: Topical anesthesia is widely used in dentistry to reduce pain caused by needle
insertion and injection of the anesthetic. However, successful anesthesia is not always …

Palatal injections are considered to be one of the most painful dental procedures. As a
result, it was important to find alternatives to this painful injection to improve children's …

In dentistry, the use of biomaterial-based drug delivery systems (DDS) aiming the release of
the active compounds directly to the site of action is slowly getting more awareness among …

Background Safe and effective local anesthesia is a prerequisite for emergency oral
surgeries and most dental treatments. Pregnancy is characterized by complex physiological …

This study reports the development of nanostructured hydrogels for the sustained release of
the eutectic mixture of lidocaine and prilocaine (both at 2.5%) for intraoral topical use. The …