Gene duplication is a prevalent phenomenon across the tree of life. The processes that lead
to the retention of duplicated genes are not well understood. Functional genomics …

For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights
into human biology. Yeast and humans share several thousand genes despite …

Although transplantation of single genes in yeast plays a key role in elucidating gene
functionality in metazoans, technical challenges hamper humanization of full pathways and …

Prediction of orthologs is an important bioinformatics pursuit that is frequently used for
inferring protein function and evolutionary analyses. The InParanoid database is a well …

Variants in membrane trafficking proteins are known to cause rare disorders with severe
symptoms. The highly conserved transport protein particle (TRAPP) complexes are key …

The recognition of the 5′ splice site (5′ ss) is one of the earliest steps of pre-mRNA
splicing. To better understand, the mechanism and regulation of 5′ ss recognition, we …

While genomic alterations are fundamental to biological evolution, enabling adaptation and
diversity, they can also result in detrimental outcomes, such as the development of genetic …

Chronic hepatitis B virus infection is the dominant cause of hepatocellular carcinoma, the
main cause of cancer death. HBx protein, a multifunctional protein, is essential for …

Kinetochores assemble on centromeres to drive chromosome segregation in eukaryotic
cells. Humans and budding yeast share most of the structural subunits of the kinetochore …

Mitochondria are considered to be the main source of reactive oxygen species (ROS) in the
cell. It was shown that in cardiac myocytes exposed to excessive oxidative stress, ROS …