Mutations of the dystrophin DMD gene, essentially deletions of one or several exons, are the
cause of two devastating and to date incurable diseases, Duchenne (DMD) and Becker …

Duchenne muscular dystrophy (DMD) is the most common childhood neuromuscular
disorder. It is caused by mutations in the DMD gene that disrupt the open reading frame …

UMD–DMD France is a knowledgebase developed through a multicenter academic effort to
provide an up‐to‐date resource of curated information covering all identified mutations in …

Recent advances in molecular therapies for Duchenne muscular dystrophy (DMD) require
precise genetic diagnosis because most therapeutic strategies are mutation-specific. To …

Duchenne muscular dystrophy (DMD) is a lethal, X-linked disorder associated with
dystrophin deficiency that results in chronic inflammation, sarcolemma damage, and severe …

We previously conducted a proof of principle; dose escalation study in Duchenne muscular
dystrophy (DMD) patients using the morpholino splice-switching oligonucleotide AVI-4658 …

In skeletal muscle, the cytolinker plectin is prominently expressed at Z-disks and the
sarcolemma. Alternative splicing of plectin transcripts gives rise to more than eight protein …

The essential product of the Duchenne muscular dystrophy (DMD) gene is dystrophin, a rod-
like protein that protects striated myocytes from contraction-induced injury,. Dystrophin …

Background Dystrophin is a large essential protein of skeletal and heart muscle. It is a
filamentous scaffolding protein with numerous binding domains. Mutations in the DMD gene …

The largest human gene is represented by the X-chromosomal dystrophin gene of 2.4
million bases, which encodes for the membrane cytoskeletal protein dystrophin. The …