The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Transcription factors (TFs) are key regulatory proteins that control the transcriptional rate of
cells by binding short DNA sequences called transcription factor binding sites (TFBS) or …

DNA/RNA motif mining is the foundation of gene function research. The DNA/RNA motif
mining plays an extremely important role in identifying the DNA-or RNA-protein binding site …

While pancreatic ductal adenocarcinomas (PDACs) are addicted to KRAS-activating
mutations, inhibitors of downstream KRAS effectors, such as the MEK1/2 kinase inhibitor …

Interactions of transcription factors (TFs) with DNA comprise a complex interplay between
base-specific amino acid contacts and readout of DNA structure. Recent studies have …

By its very nature, genomics produces large, high-dimensional datasets that are well suited
to analysis by machine learning approaches. Here, we explain some key aspects of …

Aptamers, short RNA or DNA molecules that bind distinct targets with high affinity and
specificity, can be identified using high-throughput systematic evolution of ligands by …

Chromatin immunoprecipitation followed by sequencing with next-generation technologies
(ChIP-Seq) has become the de facto standard for building genome-wide maps of regions …

Planarians have become an established model system to study regeneration and stem cells,
but the regulatory elements in the genome remain almost entirely undescribed. Here, by …

Cells adapt to environmental changes, including fluctuations in oxygen levels, through the
induction of specific gene expression programs. To identify genes regulated by hypoxia at …