2-Methoxyestradiol (2ME2) is an endogenous metabolite of estrogen that has both
antiangiogenic and antitumor effects. In preclinical models, 2ME2 showed promising activity …

In summary, preclinical studies continue to provide enthusiasm for 2ME2 as a broad-
spectrum agent. New data help resolve the roles of the diverse cellular effects of 2ME2 …

Polyphenols such as epigallocatechin-3-gallate (EGCG) from green tea extract can exert a
growth-suppressive effect on human pancreatic cancer cells in vitro. In pursuit of our …

Bcl-xL, a close homolog of Bcl2, is an important regulator of apoptosis and is overexpressed
in human cancer. Phosphorylation of Bcl-xL can be induced by microtubule-damaging drugs …

In murine embryonic fibroblasts, N-acetyl-l-cysteine (NAC), a GSH generating agent,
enhances hypoxic apoptosis by blocking the NFκB survival pathway (Qanungo, S., Wang …

Abstract The effects of 2-Methoxyestradiol (2ME)-induced apoptosis was examined in
human leukemia cells (U937 and Jurkat) in relation to mitochondrial injury, oxidative …

Comprehensive understanding of cancer‐specific survival differences in gender is critical for
cancer prevention and treatment. Based on the Surveillance Epidemiology and End Results …

In this study, we investigated the role of reduced glutathione (GSH) and nuclear factor-κB
(NFκB) in hypoxia-induced apoptosis. Hypoxia caused p53-dependent apoptosis in murine …

Estrogens function in numerous physiological processes including controlling brain cell
growth and differentiation. 2-Methoxestradiol (2-ME2), a 17β-estradiol (E2) metabolite, is …

Reactive oxygen species (ROS) act as a double-edged sword in cancer, where low levels of
ROS are beneficial but excessive accumulation leads to cancer progression. Elevated levels …