Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in …
NJ Hewitt, MJ Gómez Lechón, JB Houston… - Drug metabolism …, 2007 - Taylor & Francis
This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …
Human cytochrome P450 enzymes
FP Guengerich - Cytochrome P450: structure, mechanism, and …, 2015 - Springer
Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …
A mammalian organelle map by protein correlation profiling
Protein localization to membrane-enclosed organelles is a central feature of cellular
organization. Using protein correlation profiling, we have mapped 1,404 proteins to ten …
organization. Using protein correlation profiling, we have mapped 1,404 proteins to ten …
The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms
M Ingelman-Sundberg - Naunyn-Schmiedeberg's archives of …, 2004 - Springer
The cytochrome P450s are responsible for about 75% of phase I dependent drug
metabolism and for the metabolism of a huge amount of dietary constituents and …
metabolism and for the metabolism of a huge amount of dietary constituents and …
Herb-drug interactions and hepatotoxicity
MK Parvez, V Rishi - Current drug metabolism, 2019 - ingentaconnect.com
Background: In recent times, herbals or phytomedicines have become very popular due to
their global acceptance as a complementary and alternative remedy. While modern drugs …
their global acceptance as a complementary and alternative remedy. While modern drugs …
[PDF][PDF] HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity
MR McGill, HM Yan, A Ramachandran, GJ Murray… - …, 2011 - Wiley Online Library
Acetaminophen (APAP) overdose is the leading cause of acute liver failure in Western
countries. In the last four decades much progress has been made in our understanding of …
countries. In the last four decades much progress has been made in our understanding of …
Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells
C Rodríguez-Antona, MT Donato, A Boobis… - Xenobiotica, 2002 - Taylor & Francis
1. Cultured hepatic cells have reduced cytochrome P450 (CYP) activities in comparison with
human liver, but the mechanism (s) that underlies this circumstance is not clear. We …
human liver, but the mechanism (s) that underlies this circumstance is not clear. We …
The orphan nuclear receptor HNF4α determines PXR-and CAR-mediated xenobiotic induction of CYP3A4
RG Tirona, W Lee, BF Leake, LB Lan, CB Cline… - Nature medicine, 2003 - nature.com
The drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is thought to be involved in
the metabolism of nearly 50% of all the drugs currently prescribed. Alteration in the activity or …
the metabolism of nearly 50% of all the drugs currently prescribed. Alteration in the activity or …
Cytochrome P450 expression and regulation in the brain
W Kuban, WA Daniel - Drug Metabolism Reviews, 2021 - Taylor & Francis
The regulation of brain cytochrome P450 enzymes (CYPs) is different compared with
respective hepatic enzymes. This may result from anatomical bases and physiological …
respective hepatic enzymes. This may result from anatomical bases and physiological …