Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is
currently the main event leading to death in patients with cirrhosis. Evolving information …

The discovery of cell-free tumor and fetal DNA molecules in the plasma of cancer patients
and pregnant women, respectively, has opened up exciting opportunities in molecular …

Human liver cancer research currently lacks in vitro models that can faithfully recapitulate
the pathophysiology of the original tumor. We recently described a novel, near-physiological …

The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for
performing liquid biopsies for the assessment of solid tumors. Although its clinical potential …

Lung adenocarcinoma, the most common subtype of non-small cell lung cancer, is
responsible for more than 500,000 deaths per year worldwide. Here, we report exome and …

Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and
its underlying etiology and genomic structure are heterogeneous. Here we provide a whole …

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Here, we
performed high-resolution copy-number analysis on 125 HCC tumors and whole-exome …

Cancer immunoediting, the process by which the immune system controls tumour outgrowth
and shapes tumour immunogenicity, is comprised of three phases: elimination, equilibrium …

To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with
somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two …

To survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted
massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular …