Type 2 diabetes mellitus (T2DM) is a very complex and multifactorial metabolic disease
characterized by insulin resistance and β cell failure leading to elevated blood glucose …

Advanced glycation endproducts (AGEs) form by Maillard-reactions after initial binding of
aldehydes with amines or amides in heated foods or in living organisms. The mechanisms of …

Despite new and effective drug therapies, insulin resistance (IR), type 2 diabetes mellitus
(T2D) and its complications remain major medical challenges. It is accepted that IR, often …

Advanced glycation end products (AGEs) are a heterogeneous group of molecules
produced, non‐enzymatically, from the interaction between reducing sugars and the free …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Glycative stress, caused by the accumulation of cytotoxic and irreversibly-formed sugar-
derived advanced glycation end-products (AGEs), contributes to morbidity associated with …

The epidemics of insulin resistance (IR) and type 2 diabetes (T2D) affect the first world as
well as less-developed countries, and now affect children as well. Persistently elevated …

Persistently elevated oxidative stress and inflammation precede or occur during the
development of type 1 or type 2 diabetes mellitus and precipitate devastating complications …

It was initially believed that advanced glycation end products (AGEs) arose primarily from
endogenous sources, and that excess amounts were only present in patients with diabetes …

Methylglyoxal (MG) is a highly reactive compound derived mainly from glucose and fructose
metabolism. This metabolite has been implicated in diabetic complications as it is a strong …