Designing microbial cell factories for the production of chemicals
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …
as an essential alternative to address pressing environmental issues arising from our heavy …
The evolution of genome mining in microbes–a review
Covering: 2006 to 2016 The computational mining of genomes has become an important
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
part in the discovery of novel natural products as drug leads. Thousands of bacterial …
Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
MA Skinnider, CW Johnston… - Nature …, 2020 - nature.com
Novel antibiotics are urgently needed to address the looming global crisis of antibiotic
resistance. Historically, the primary source of clinically used antibiotics has been microbial …
resistance. Historically, the primary source of clinically used antibiotics has been microbial …
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
Many antibiotics, chemotherapeutics, crop protection agents and food preservatives
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …
originate from molecules produced by bacteria, fungi or plants. In recent years, genome …
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics,
insecticides and other high-value chemicals. Genome mining of gene clusters that encode …
insecticides and other high-value chemicals. Genome mining of gene clusters that encode …
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters
Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …
metabolites, our knowledge of their diversity remains limited. Here, we used a novel …
PRISM 3: expanded prediction of natural product chemical structures from microbial genomes
Microbial natural products represent a rich resource of pharmaceutically and industrially
important compounds. Genome sequencing has revealed that the majority of natural …
important compounds. Genome sequencing has revealed that the majority of natural …
Computational approaches to natural product discovery
MH Medema, MA Fischbach - Nature chemical biology, 2015 - nature.com
Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …
genome mining has been captivating: genomics and bioinformatics would transform …
Biologically active secondary metabolites from the fungi
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
Bacterial and fungal secondary metabolism is a rich source of novel bioactive compounds
with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol …
with potential pharmaceutical applications as antibiotics, anti-tumor drugs or cholesterol …