Cancer-associated fibroblasts: an emerging target against esophageal squamous cell carcinoma

L Qiu, J Yue, L Ding, Z Yin, K Zhang, H Zhang - Cancer letters, 2022 - Elsevier
Esophageal squamous cell carcinoma (ESCC) is one of the most common human
malignancies worldwide and is associated with high morbidity and mortality. More than 70 …

Can natural products targeting EMT serve as the future anticancer therapeutics?

S Anwar, JA Malik, S Ahmed, VA Kameshwar, J Alanazi… - Molecules, 2022 - mdpi.com
Cancer is the leading cause of death and has remained a big challenge for the scientific
community. Because of the growing concerns, new therapeutic regimens are highly …

Resveratrol nanoparticle attenuates metastasis and angiogenesis by deregulating inflammatory cytokines through inhibition of CAFs in oral cancer by CXCL-12/IL-6 …

R Pradhan, S Paul, B Das, S Sinha, SR Dash… - The Journal of …, 2023 - Elsevier
Cancer-associated fibroblasts (CAFs) are one of the highly abundant components in the
tumor microenvironment (TME). They secrete several cytokines, which amplified tumor …

Macrophage-derived extracellular vesicles: A promising tool for personalized cancer therapy

A Barone, N d'Avanzo, MC Cristiano, D Paolino… - Biomedicines, 2022 - mdpi.com
The incidence of cancer is increasing dramatically, affecting all ages of the population and
reaching an ever higher worldwide mortality rate. The lack of therapies' efficacy is due to …

The prognostic marker elastin correlates with epithelial–mesenchymal transition and vimentin‐positive fibroblasts in gastric cancer

T Fang, L Zhang, X Yin, Y Wang… - The Journal of …, 2023 - Wiley Online Library
Elastin (ELN) fibers are essential constituents of the tumor microenvironment of gastric
cancer (GC). However, few studies have investigated the clinical prognostic significance of …

Engineered exosomes as theranostic platforms for cancer treatment

X Yang, X Xie, S Liu, W Ma, Z Zheng… - … Science & Engineering, 2023 - ACS Publications
Tremendous progress in nanotechnology and nanomedicine has made a significant positive
effect on cancer treatment by integrating multicomponents into a single multifunctional …

Epigenetic regulation of stem cells in lung cancer oncogenesis and therapy resistance

J Wu, J Feng, Q Zhang, Y He, C Xu, C Wang… - Frontiers in …, 2023 - frontiersin.org
Epigenetics plays an important role in regulating stem cell signaling, as well as in the
oncogenesis of lung cancer and therapeutic resistance. Determining how to employ these …

The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth

R Pradhan, A Kundu, CN Kundu - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
It is a well-known fact that cancer can be augmented by infections and inflammation. In fact,
chronic inflammation establishes a tumor-supporting-microenvironment (TME), which …

d-arabinose induces cell cycle arrest by promoting autophagy via p38 MAPK signaling pathway in breast cancer

Z Tang, H Song, S Qin, Z Tian, C Zhang, Y Zhou… - Scientific Reports, 2024 - nature.com
Breast cancer patients often have a poor prognosis largely due to lack of effective targeted
therapy. It is now well established that monosaccharide enhances growth retardation and …

Role of cancer-associated fibroblasts in the progression, therapeutic resistance and targeted therapy of oesophageal squamous cell carcinoma

M Xue, Y Tong, Y Xiong, C Yu - Frontiers in Oncology, 2023 - frontiersin.org
Oesophageal squamous cell carcinoma (ESCC) is one of the most aggressive malignant
tumours with high morbidity and mortality. Although surgery, radiotherapy and …