Dural immune cells, CGRP, and migraine

LK Balcziak, AF Russo - Frontiers in neurology, 2022 - frontiersin.org
Migraine is the most common neurological disorder in the world, affecting 12% of the
population. Migraine involves the central nervous system, trigeminal nerves and meninges …

Autoimmunity in dry eye disease–an updated review of evidence on effector and memory Th17 cells in disease pathogenicity

Y Chen, R Dana - Autoimmunity reviews, 2021 - Elsevier
Abstract The classic Th1/Th2 dogma has been significantly reshaped since the subsequent
introduction of several new T helper cell subsets, among which the most intensively …

Immunomodulatory role of neuropeptides in the cornea

S Puri, BM Kenyon, P Hamrah - Biomedicines, 2022 - mdpi.com
The transparency of the cornea along with its dense sensory innervation and resident
leukocyte populations make it an ideal tissue to study interactions between the nervous and …

The role of corneal afferent neurons in regulating tears under normal and dry eye conditions

ID Meng, M Kurose - Experimental eye research, 2013 - Elsevier
The cornea is one of several orofacial structures requiring glandular secretion for proper
lubrication. Glandular secretion is regulated through a neural reflex initiated by trigeminal …

Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex

JH Harkness, AE Gonzalez, PN Bushana… - Brain Structure and …, 2021 - Springer
Perineuronal nets (PNNs) surrounding fast-spiking, parvalbumin (PV) interneurons provide
excitatory: inhibitory balance, which is impaired in several disorders associated with altered …

Cocaine exposure modulates perineuronal nets and synaptic excitability of fast-spiking interneurons in the medial prefrontal cortex

ML Slaker, ET Jorgensen, DM Hegarty, X Liu, Y Kong… - Eneuro, 2018 - eneuro.org
We previously reported that perineuronal nets (PNNs) are required for cocaine-associated
memories. Perineuronal nets are extracellular matrix that primarily surrounds parvalbumin …

Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray

AR Wilson-Poe, MM Morgan, SA Aicher, DM Hegarty - Neuroscience, 2012 - Elsevier
The periaqueductal gray (PAG) is part of a descending pain modulatory system that, when
activated, produces widespread and profound antinociception. Microinjection of either …

The intriguing role of neuropeptides at the ocular surface

F Sabatino, A Di Zazzo, L De Simone, S Bonini - The ocular surface, 2017 - Elsevier
In recent decades, the role of neuropeptides in physiology and pathology has been
elucidated. Various neuropeptides are expressed at the ocular surface, where they facilitate …

Vesicular glutamate transporter isoforms: the essential players in the somatosensory systems

FX Zhang, SN Ge, YL Dong, J Shi, YP Feng, Y Li… - Progress in …, 2018 - Elsevier
In nervous system, glutamate transmission is crucial for centripetal conveyance and cortical
perception of sensory signals of different modalities, which necessitates vesicular glutamate …

Immune regulation of the ocular surface

Y Chen, S Wang, H Alemi, T Dohlman… - Experimental eye research, 2022 - Elsevier
Despite constant exposure to various environmental stimuli, the ocular surface remains
intact and uninflamed while maintaining the transparency of the cornea and its visual …