Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …
E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …
Drug nanocrystals: in vivo performances
L Gao, G Liu, J Ma, X Wang, L Zhou, X Li - Journal of controlled release, 2012 - Elsevier
Over the past few decades, there has been a considerable research interest in drug
nanocrystal system as a pharmaceutical approach for poorly soluble drugs. At the beginning …
nanocrystal system as a pharmaceutical approach for poorly soluble drugs. At the beginning …
Application of drug nanocrystal technologies on oral drug delivery of poorly soluble drugs
L Gao, G Liu, J Ma, X Wang, L Zhou, X Li… - Pharmaceutical …, 2013 - Springer
The limited solubility and dissolution rate exhibited by poorly soluble drugs is major
challenges in the pharmaceutical process. Following oral administration, the poorly soluble …
challenges in the pharmaceutical process. Following oral administration, the poorly soluble …
Pharmaceutical excipients—quality, regulatory and biopharmaceutical considerations
Practically all medications contain excipients, which are added for the purpose of production
enhancement, patient acceptability, improving stability, controlling release etc. Typically …
enhancement, patient acceptability, improving stability, controlling release etc. Typically …
Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
All cells necessarily contain tens, if not hundreds, of carriers for nutrients and intermediary
metabolites, and the human genome codes for more than 1000 carriers of various kinds …
metabolites, and the human genome codes for more than 1000 carriers of various kinds …
Biopharmaceutical aspects and implications of excipient variability in drug product performance
P Zarmpi, T Flanagan, E Meehan, J Mann… - European Journal of …, 2017 - Elsevier
Abstract Implementation of Quality by Design approaches in pharmaceutical industry
requires a sound understanding of the parameters triggering final product variability …
requires a sound understanding of the parameters triggering final product variability …
Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II …
HD Williams, MU Anby, P Sassene… - Molecular …, 2012 - ACS Publications
The LFCS Consortium was established to develop standardized in vitro tests for lipid-based
formulations (LBFs) and to examine the utility of these tests to probe the fundamental …
formulations (LBFs) and to examine the utility of these tests to probe the fundamental …
Interactions between active pharmaceutical ingredients and excipients affecting bioavailability: impact on bioequivalence
A García-Arieta - European Journal of Pharmaceutical Sciences, 2014 - Elsevier
The aim of the present paper is to illustrate the impact that excipients may have on the
bioavailability of drugs and to review existing US-FDA, WHO and EMA regulatory guidelines …
bioavailability of drugs and to review existing US-FDA, WHO and EMA regulatory guidelines …
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in …
HD Williams, P Sassene, K Kleberg, M Calderone… - Pharmaceutical …, 2013 - Springer
Purpose Recent studies have shown that digestion of lipid-based formulations (LBFs) can
stimulate both supersaturation and precipitation. The current study has evaluated the drug …
stimulate both supersaturation and precipitation. The current study has evaluated the drug …