Lung diseases remain a significant and devastating cause of morbidity and mortality
worldwide. In contrast to many other major diseases, lung diseases notably chronic …

New paradigms have been recently proposed in the pathogenesis of both chronic
obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), evidencing …

Lung epithelial cell damage and dysfunctional repair play a role in the development of lung
disease. Effective repair likely requires the normal functioning of alveolar stem/progenitor …

Fetal lung underdevelopment, also known as pulmonary hypoplasia, is characterized by
decreased lung growth and maturation. The most common birth defect found in babies with …

COPD is characterised by tissue destruction and inflammation. Given the lack of curative
treatments and the progressive nature of the disease, new treatments for COPD are highly …

The alternative activation of macrophages in the lungs has been considered as a major
factor promoting pulmonary fibrogenesis; however, the mechanisms underlying this …

Extracellular vesicles (EVs) derived from amniotic fluid stem cells (AFSCs) mediate anti-
apoptotic, pro-angiogenic, and immune-modulatory effects in multiple disease models, such …

Oligohydramnios (decreased amniotic fluid volume for gestational age) is a severe condition
associated with high morbidity and mortality mainly due to fetal pulmonary hypoplasia …

Bronchopulmonary dysplasia, the chronic lung disease of prematurity, is the most common
complication in extremely premature infants (born before 28 wk gestation). Despite …

Amniotic fluid (AF) provides critical biological and physical support for the developing fetus.
While AF is an excellent source of progenitor cells with regenerative properties, recent …