Understanding breast cancer: From conventional therapies to repurposed drugs

B Costa, I Amorim, F Gärtner, N Vale - European Journal of Pharmaceutical …, 2020 - Elsevier
Breast cancer is the most common cancer among women and is considered a developed
country disease. Moreover, is a heterogenous disease, existing different types and stages of …

Molecular and pathobiological insights of bikunin/UTI in cancer

AJ Lepedda, G Nieddu, C Cannas… - Molecular Biology Reports, 2023 - Springer
Bikunin is a small chondroitin sulfate proteoglycan (PG) with Ser-protease inhibitory activity
that plays pleiotropic roles in health and disease. It is involved in several physiological …

[HTML][HTML] Anticancer effects of sweet potato protein on human colorectal cancer cells

PG Li, TH Mu, L Deng - World Journal of Gastroenterology: WJG, 2013 - ncbi.nlm.nih.gov
AIM: To investigate the effects of proteins purified from sweet potato storage roots on human
colorectal cancer cell lines. METHODS: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium …

Taxanes sensitize prostate cancer cells to TRAIL-induced apoptotic synergy via endoplasmic reticulum stress

KA Grayson, JM Hope, W Wang… - Molecular cancer …, 2021 - AACR
Docetaxel and cabazitaxel are guideline-chemotherapy treatments for metastatic castration-
resistant prostate cancer (mCRPC), which comprises the majority of prostate cancer deaths …

Overcoming TRAIL-resistance by sensitizing prostate cancer 3D spheroids with taxanes

KA Grayson, N Jyotsana, N Ortiz-Otero, MR King - PLoS One, 2021 - journals.plos.org
Three-dimensional spheroid cultures have been shown to better physiologically mimic the
cell-cell and cell-matrix interactions that occur in solid tumors more than traditional 2D cell …

A novel guaiane sesquiterpene derivative, guai-2-en-10α-ol, from Ulva fasciata Delile inhibits EGFR/PI3K/Akt signaling and induces cytotoxicity in triple-negative …

T Pragna Lakshmi, S Vajravijayan, M Moumita… - Molecular and cellular …, 2018 - Springer
A novel guaiane sesquiterpene derivative, guai-2-en-10α-ol, from Ulva fasciata Delile
exhibits antimicrobial property. U. fasciata extract was reported to exhibit cytotoxicity against …

Piperlongumine and immune cytokine TRAIL synergize to promote tumor death

J Li, CC Sharkey, MR King - Scientific reports, 2015 - nature.com
Malignant transformation results in increased levels of reactive oxygen species (ROS).
Adaption to this toxic stress allows cancer cells to proliferate. Recently, piperlongumine (PL) …

Piperlongumine potentiates the effects of gemcitabine in in vitro and in vivo human pancreatic cancer models

J Mohammad, H Dhillon, S Chikara, S Mamidi… - …, 2017 - pmc.ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers due to a late
diagnosis and poor response to available treatments. There is a need to identify …

Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway

Z Liu, X Zhu, C Xu, F Min, G Yu… - Drug Development …, 2023 - Wiley Online Library
Prostate cancer is a male malignant tumor disease with high incidence and mortality. This
study was designed to explore the effects of ulinastatin (UTI) on the malignant progression of …

Ulinastatin reduces the resistance of liver cancer cells to epirubicin by inhibiting autophagy

B Song, Q Bian, CH Shao, G Li, AA Liu, W Jing, R Liu… - PLoS …, 2015 - journals.plos.org
During chemotherapy, drug resistance caused by autophagy remains a major challenge to
successful treatment of cancer patients. The purpose of this study is to show that ulinastatin …