Abstract The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin
(mTOR) signaling axis plays a central role in cell proliferation, growth, and survival under …

Multiple studies have demonstrated that interaction with the bone marrow stromal
microenvironment contributes to the survival of leukemia cells. One explanation for this …

Abstract SDF-1α/CXCR4 signaling plays a key role in leukemia/bone marrow
microenvironment interactions. We previously reported that bone marrow–derived stromal …

We examined the role of microRNAs (miRNAs) in targeting the stromal-derived factor
1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Microarray …

Chemokine ligand/receptor interactions affect melanoma cell growth, stimulate or inhibit
angiogenesis, recruit leukocytes, promote metastasis, and alter the gene expression profile …

Background: The PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathway plays
a central role in cell growth, proliferation and survival not only under physiological …

OBJECTIVE: The chemokine receptor CXCR4 and its ligand CXCL12 are involved in the
progression and dissemination of a diverse number of solid and hematological …

CXCR4 is expressed on leukaemia cells and haematopoietic stem cells (HSCs), and its
ligand stromal‐derived factor 1 (SDF‐1) is produced abundantly by stromal cells in the bone …

Simple Summary The suppressors of cytokine signaling (SOCS) are known cytokine-
inducible negative regulators of JAK/STAT and other cell signaling pathways. Deregulation …

We analysed, by flow cytometry, the “adhesive” phenotype of acute myelogenous leukemia
(AML) cells from 36 patients treated in our institution. In univariate analysis, the main …