Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery
L Nair, H Chung, U Basu - Nature reviews Molecular cell biology, 2020 - nature.com
Much of the mammalian genome is transcribed, generating long non-coding RNAs
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …
(lncRNAs) that can undergo post-transcriptional surveillance whereby only a subset of the …
Selection on synonymous sites: the unwanted transcript hypothesis
Although translational selection to favour codons that match the most abundant tRNAs is not
readily observed in humans, there is nonetheless selection in humans on synonymous …
readily observed in humans, there is nonetheless selection in humans on synonymous …
Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells
Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …
regulating diverse biological processes. The RNA exosome, the predominant 3′ RNA …
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism
I Gritti, V Basso, D Rinchai, F Corigliano, S Pivetti… - The EMBO …, 2022 - embopress.org
The ribonuclease DIS3 is one of the most frequently mutated genes in the hematological
cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease …
cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease …
DIS3: The Enigmatic Gene in Multiple Myeloma
Y Ohguchi, H Ohguchi - International Journal of Molecular Sciences, 2023 - mdpi.com
Recent studies have revealed the genetic aberrations involved in the initiation and
progression of various cancers, including multiple myeloma (MM), via next-generation …
progression of various cancers, including multiple myeloma (MM), via next-generation …
The RNA exosome and human disease
The evolutionarily conserved RNA exosome is a multisubunit ribonuclease complex that
processes and/or degrades numerous RNAs. Recently, mutations in genes encoding both …
processes and/or degrades numerous RNAs. Recently, mutations in genes encoding both …
A 15-long non-coding RNA signature to improve prognosis prediction of cervical squamous cell carcinoma
X Mao, X Qin, L Li, J Zhou, M Zhou, X Li, Y Xu… - Gynecologic …, 2018 - Elsevier
Long non-coding RNAs (lncRNAs), which have little or no protein-coding capacity, caught a
particular interest since their potential roles in the cancer paradigm. As the most common …
particular interest since their potential roles in the cancer paradigm. As the most common …
[HTML][HTML] DIS3 depletion in multiple myeloma causes extensive perturbation in cell cycle progression and centrosome amplification
VK Favasuli, D Ronchetti, I Silvestris, N Puccio… - …, 2024 - ncbi.nlm.nih.gov
DIS3 gene mutations occur in approximately 10% of patients with multiple myeloma (MM);
furthermore, DIS3 expression can be affected by monosomy 13 and del (13q), found in …
furthermore, DIS3 expression can be affected by monosomy 13 and del (13q), found in …
pyComBat, a Python tool for batch effects correction in high-throughput molecular data using empirical Bayes methods
A Behdenna, M Colange, J Haziza, A Gema, G Appé… - BMC …, 2023 - Springer
Background Variability in datasets is not only the product of biological processes: they are
also the product of technical biases. ComBat and ComBat-Seq are among the most widely …
also the product of technical biases. ComBat and ComBat-Seq are among the most widely …
Distinct and evolutionary conserved structural features of the human nuclear exosome complex
P Gerlach, JM Schuller, F Bonneau, J Basquin… - Elife, 2018 - elifesciences.org
The nuclear RNA exosome complex mediates the processing of structured RNAs and the
decay of aberrant non-coding RNAs, an important function particularly in human cells. Most …
decay of aberrant non-coding RNAs, an important function particularly in human cells. Most …