CRISPR/Cas (clustered regularly interspaced short palindromic repeats linked to Cas
nuclease) technology has revolutionized many aspects of genetic engineering research …

The extreme shortage of human donor organs for treatment of patients with end-stage organ
failures is well known. Xenotransplantation, which might provide unlimited organ supply, is a …

Xenogeneic transplantation and tolerance in the era of CRISP... : Current Opinion in Organ
Transplantation Xenogeneic transplantation and tolerance in the era of CRISPR-Cas9 …

The recent advent of the Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)‐CRISPR associated protein 9 (Cas9) system for precise genome editing has …

One of the primary concerns for the survival of the human species is the growing demand for
food brought on by an increasing global population. New developments in genome-editing …

Xenotransplantation using genetically-engineered pig organs offers an unlimited supply of
organs for patients with end-stage organ failure. There are three known pig xenoantigens …

The development of high-precision genome editing tools, such as targeted nucleases, has
accelerated advances in fundamental human medicine, animal science, animal breeding, as …

Xenotransplantation, mostly from pig donors, represents a major untapped source to
mitigate the shortage of organs suitable for transplantation. This chapter outlines the major …

This year marks the 33rd anniversary of the first transgenic pigs generated by microinjection
(Hammer et al., 1985), the 22nd anniversary of the birth of Dolly the sheep, generated by …

This thesis examines plasma skimming in the spiral groove bearing (SGB) of a centrifugal
blood pump. Plasma skimming is the phenomenon by which erythrocytes and plasma are …