Mechanism of splicing regulation of spinal muscular atrophy genes

RN Singh, NN Singh - RNA Metabolism in Neurodegenerative Diseases, 2018 - Springer
Spinal muscular atrophy (SMA) is one of the major genetic disorders associated with infant
mortality. More than 90% cases of SMA result from deletions or mutations of Survival Motor …

[HTML][HTML] RBM10: structure, functions, and associated diseases

A Inoue - Gene, 2021 - Elsevier
RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of
primary transcripts. Recently, research on RBM10 has become increasingly active owing to …

Late‐life exercise mitigates skeletal muscle epigenetic aging

KA Murach, AL Dimet‐Wiley, Y Wen, CR Brightwell… - Aging …, 2022 - Wiley Online Library
There are functional benefits to exercise in muscle, even when performed late in life, but the
contributions of epigenetic factors to late‐life exercise adaptation are poorly defined. Using …

Drug delivery approaches for HuR-targeted therapy for lung cancer

R Raguraman, S Shanmugarama, M Mehta… - Advanced drug delivery …, 2022 - Elsevier
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …

Mutational landscape of non-muscle-invasive bladder cancer

CD Hurst, MA Knowles - Urologic Oncology: Seminars and Original …, 2022 - Elsevier
Non-muscle-invasive bladder cancer (NMIBC) includes stage Ta and stage T1 tumors and
carcinoma in situ (CIS). Grading of Ta tumors subdivides these lesions into papillary …

A Multilayered Control of the Human Survival Motor Neuron Gene Expression by Alu Elements

EW Ottesen, J Seo, NN Singh, RN Singh - Frontiers in Microbiology, 2017 - frontiersin.org
Humans carry two nearly identical copies of Survival Motor Neuron gene: SMN1 and SMN2.
Mutations or deletions of SMN1, which codes for SMN, cause spinal muscular atrophy …

Rbm10 regulates inflammation development via alternative splicing of Dnmt3b

T Atsumi, H Suzuki, JJ Jiang, Y Okuyama… - International …, 2017 - academic.oup.com
Abstract RNA-binding motif 10 (Rbm10) is an RNA-binding protein that regulates alternative
splicing, but its role in inflammation is not well defined. Here, we show that Rbm10 controls …

RBM10, a new regulator of p53

JH Jung, H Lee, SX Zeng, H Lu - Cells, 2020 - mdpi.com
The tumor suppressor p53 acts as a transcription factor that regulates the expression of a
number of genes responsible for DNA repair, cell cycle arrest, metabolism, cell migration …

RBM10: Harmful or helpful‐many factors to consider

JJ Loiselle, LC Sutherland - Journal of cellular biochemistry, 2018 - Wiley Online Library
RBM10 is an RNA binding motif (RBM) protein expressed in most, if not all, human and
animal cells. Interest in RBM10 is rapidly increasing and its clinical importance is highlighted …

[HTML][HTML] Potential predictive value of serum targeted metabolites and concurrently mutated genes for EGFR-TKI therapeutic efficacy in lung adenocarcinoma patients …

X Han, R Luo, L Wang, L Zhang, T Wang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
There is a discrepancy in the efficacy of epidermal growth factor receptor-tyrosine kinase
inhibitor (EGFR-TKI) treatment for advanced lung adenocarcinoma (LUAD) patients with …