The ability to introduce foreign genes into the germ line and the successful expression of the
inserted gene in the organism have allowed the genetic manipulation of animals on an …

Fetal nigral grafts have been demonstrated to survive, secrete dopamine, form synaptic
connections with host neurons, and reverse behavioral disturbances in experimental models …

• By using stereotaxic surgical techniques, ventral mesencephalic tissues from aborted
human fetuses of 8 to 10 weeks' gestational age were implanted unilaterally into the striata …

A patient with Parkinson's disease received bilateral fetal human nigral implants from six
donors aged 6.5 to 9 weeks post‐conception. Eighteen months following a post‐operative …

• In an effort to improve the clinical signs of Parkinson's disease, we have implanted
mesencephalic dopamine cells from a 7-week human embryo into the caudate and putamen …

The Europäische Akademie is concerned with the study of the consequences of scientific
and technological advance both for the individual and for society at large as well as for the …

One therapeutic approach to treating Parkinson's disease is to convert endogenous striatal
cells into levo-3, 4-dihydroxyphenylalanine (L-dopa)-producing cells. A defective herpes …

The successful grafting of homotopic tissue (see Table 1 for terminology), ie neuronal tissue,
to the brain has recently increased the interest in the brain as an immunologically privileged …

Objective The main goal of dopamine cell replacement therapy in Parkinson disease (PD) is
to provide clinical benefit mediated by graft survival with nigrostriatal reinnervation. We …

Stem cells are a versatile source for cell therapy. Their use is particularly significant for the
treatment of neurological disorders for which no definitive conventional medical treatment is …