Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Osteoporosis, is the most common bone disorder worldwide characterized by low bone
mineral density, leaving affected bones vulnerable to fracture. Bone homeostasis depends …

Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Ageing of the immune system, or immunosenescence, contributes to the morbidity and
mortality of the elderly,. To define the contribution of immune system ageing to organism …

Abstract The coronavirus disease 2019 (COVID-19) pandemic is a global health threat with
particular risk for severe disease and death in older adults and in adults with age-related …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic
drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …