Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

The amyloid hypothesis, which has been the predominant framework for research in
Alzheimer's disease (AD), has been the source of considerable controversy. The amyloid …

Several lines of recent evidence indicate that the amyloid precursor protein-derived C-
terminal fragments (APP-CTFs) could correspond to an etiological trigger of Alzheimer's …

The amyloid precursor protein (APP) has occupied a central position in Alzheimer's disease
(AD) pathophysiology, in large part due to the seminal role of amyloid-β peptide (Aβ), a …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

Abstract β-Amyloid precursor protein (APP) and its cleaved products are strongly implicated
in Alzheimer's disease (AD). Endosomes are highly active APP processing sites, and …

In Alzheimer disease, increased β-secretase (BACE1) activity has been associated with
neurodegeneration and accumulation of amyloid precursor protein (APP) products. Thus …

Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to
neuronal loss in Alzheimer's disease (AD). However, the causal link between Aβ and neuron …

Background Alzheimer's disease (AD) is the most frequent and costly neurodegenerative
disorder. Although diverse lines of evidence suggest that the amyloid precursor protein …

We injected a combination of the β-amyloids (Aβs) Aβ40 and Aβ43 to “seed” formation of
amyloid deposits in the dorsal dentate gyrus of rats in vivo, on the basis of a theory of. Rats …