E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Cell-cell adhesions are critical for the development and maintenance of tissues. Present at
sites of cell-cell contact are the adherens junctions and tight junctions. The adherens …

β-catenin (encoded by CTNNB1) is a subunit of the cell surface cadherin protein complex
that acts as an intracellular signal transducer in the WNT signaling pathway; alterations in its …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

Adherens junctions and Tight junctions comprise two modes of cell–cell adhesion that
provide different functions. Both junctional complexes are proposed to associate with the …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

ABSTRACT β-Catenin is a central component of both the cadherin-catenin cell adhesion
complex and the Wnt signaling pathway. We have investigated the role of β-catenin during …

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease
characterized by the presence of adenomatous polyps in the colon and rectum, with …

Reactive oxygen species (ROS) are generated at sites of inflammation and injury, and at low
levels, ROS can function as signaling molecules participating as signaling intermediates in …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …