The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

In the context of impact on human health, nitrite/nitrate and related nitrogen species such as
nitric oxide (NO) are a matter of increasing scientific controversy. An increase in the content …

Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …

Nitrate, an inorganic anion abundant in vegetables, is converted in vivo to bioactive nitrogen
oxides including NO. We recently demonstrated that dietary nitrate reduces oxygen cost …

Sepsis is one of the main causes of death among critically ill patients. Sepsis pathogenesis
includes infection by gram-negative and gram-positive bacteria, fungi, or both; exacerbated …