New insights into YAP/TAZ-TEAD-mediated gene regulation and biological processes in cancer

Y Zhao, M Sheldon, Y Sun, L Ma - Cancers, 2023 - mdpi.com
Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …

Towards single cell encapsulation for precision biology and medicine

P Gupta, O Alheib, JW Shin - Advanced Drug Delivery Reviews, 2023 - Elsevier
The primary impetus of therapeutic cell encapsulation in the past several decades has been
to broaden the options for donor cell sources by countering against rejection by the host …

[HTML][HTML] Crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair

L Wang, T Zhu, Y Kang, J Zhang, J Du, H Gao, S Chen… - Bioactive Materials, 2022 - Elsevier
Electrospun fibers, with proven ability to promote tissue regeneration, are widely being
explored for rotator cuff repairing. However, without post treatment, the microstructure of the …

[HTML][HTML] Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations

Y Oguma, Y Kuroda, S Wakao, Y Kushida, M Dezawa - Iscience, 2022 - cell.com
Somatic stem cells are advantageous research targets for understanding the properties
required to maintain stemness. Human bone marrow-mesenchymal stromal cells (BM …

Assessing Biomaterial‐Induced Stem Cell Lineage Fate by Machine Learning‐Based Artificial Intelligence

Y Zhou, X Ping, Y Guo, BC Heng, Y Wang… - Advanced …, 2023 - Wiley Online Library
Current functional assessment of biomaterial‐induced stem cell lineage fate in vitro mainly
relies on biomarker‐dependent methods with limited accuracy and efficiency. Here a …

Matrix biophysical cues direct mesenchymal stromal cell functions in immunity

SW Wong, S Lenzini, R Giovanni, K Knowles, JW Shin - Acta biomaterialia, 2021 - Elsevier
Hydrogels have been used to design synthetic matrices that capture salient features of
matrix microenvironments to study and control cellular functions. Recent advances in …

“Slow walk” mimetic tensile loading maintains human meniscus tissue resident progenitor cells homeostasis in photocrosslinked gelatin hydrogel

J Sun, YT Chan, KWK Ho, L Zhang, L Bian, RS Tuan… - Bioactive Materials, 2023 - Elsevier
Meniscus, the cushion in knee joint, is a load-bearing tissue that transfers mechanical forces
to extracellular matrix (ECM) and tissue resident cells. The mechanoresponse of human …

Optimization strategies for mesenchymal stem cell-based analgesia therapy: a promising therapy for pain management

J Zhang, P Wu, Q Wen - Stem Cell Research & Therapy, 2024 - Springer
Pain is a very common and complex medical problem that has a serious impact on
individuals' physical and mental health as well as society. Non-steroidal anti-inflammatory …

Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells by Hydrogel Encapsulation

HY Cheng, MR Anggelia, SC Liu, CF Lin, CH Lin - Cells, 2024 - mdpi.com
Mesenchymal stromal cells (MSCs) showcase remarkable immunoregulatory capabilities in
vitro, positioning them as promising candidates for cellular therapeutics. However, the …

An in vitro culture platform to study the extracellular matrix remodeling potential of human mesenchymal stem cells

MH Kim, SY Tan, K Yamahara, M Kino-Oka - Acta Biomaterialia, 2023 - Elsevier
The ability of mesenchymal stem cells (MSCs) to synthesize and degrade extracellular
matrix (ECM) is important for MSC-based therapies. However, the therapeutic effects …