The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

Despite advances in the knowledge of tooth morphogenesis and differentiation, relatively
little is known about the aetiology and molecular mechanisms underlying supernumerary …

The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

Oligodontia is the congenital absence of six or more teeth and comprises the more severe
forms of tooth agenesis. Many genes have been implicated in the etiology of tooth agenesis …

Localized sources of morphogens, called signalling centres, play a fundamental role in
coordinating tissue growth and cell fate specification during organogenesis. However, how …

In humans, inherited variation in the number, size, and shape of teeth within the dentitions
are relatively common, while rarer defects of hard tissue formation, including amelogenesis …

Previous studies have suggested that Bmp4 is a key Msx1-dependent mesenchymal
odontogenic signal for driving tooth morphogenesis through the bud-to-cap transition …

Teeth organogenesis develops through a well-ordered series of inductive events involving
genes and BMP, FGF, SHH and WNT represent the main signalling pathways that regulate …

Tooth agenesis is one of the most common congenital malformations in humans.
Hypodontia can either occur as an isolated condition (non-syndromic hypodontia) or can be …

Tooth agenesis and orofacial clefts represent the most common developmental anomalies
and their co-occurrence is often reported in patients as well in animal models. The aim of the …