Advances in nanomedicine, coupled with novel methods of creating advanced materials at
the nanoscale, have opened new perspectives for the development of healthcare and …

The H2AX histone protein is rapidly phosphorylated at the serine-139 position (γH2AX) in
response to a broad range of DNA lesions. γH2AX induction is one of the earliest events in …

SMA is an inherited disease that leads to loss of motor function and ambulation and a
reduced life expectancy. We have been working to develop orally administrated …

The phosphorylation of histone variant H2AX and formation of γH2AX is a primary response
to the DNA double-strand breaks (DSBs). Detection of γH2AX is a robust and sensitive tool …

The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

The conventional battery for genotoxicity testing is not well suited to assessing the large
number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide …

ToxTracker is an in vitro mammalian stem cell‐based reporter assay that detects activation
of specific cellular signaling pathways (DNA damage, oxidative stress, and/or protein …

Beauvericin (BEA) and Enniatins (ENN) are mycotoxins produced by Fusarium fungi
detected in food and feed; there are insufficient data to establish their reference values. To …

The in vitro MultiFlow DNA Damage assay multiplexes p53, γH2AX, phospho-histone H3,
and polyploidization biomarkers into 1 flow cytometric analysis (Bryce, SM, Bernacki, DT …

In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology
Technical Committee hosted a workshop to discuss whether mode of action (MOA) …