During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

Spatially resolved transcriptomic technologies are promising tools to study complex
biological processes such as mammalian embryogenesis. However, the imbalance between …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

The turnover of the intestinal epithelium is driven by multipotent LGR5+ crypt-base columnar
cells (CBCs) located at the bottom of crypt zones. However, CBCs are lost following injury …

Excessive production of inflammatory chemokines and reactive oxygen species (ROS) can
cause a feedback cycle of inflammation response that has a negative effect on cutaneous …

In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …

Human oocytes are prone to assembling meiotic spindles with unstable poles, which can
favor aneuploidy in human eggs. The underlying causes of spindle instability are unknown …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

Gene co-expression networks can be used to associate genes of unknown function with
biological processes, to prioritize candidate disease genes or to discern transcriptional …