Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Tumor immunotherapy, which targets immune checkpoints, presents a promising strategy for
the treatment of various cancer types. However, current clinical data indicate challenges in …

Non-alcoholic fatty liver disease (NAFLD) and its more advanced form, non-alcoholic
steatohepatitis (NASH), have become global health challenges with significant morbidity …

Increasing evidence hints that DNA hypermethylation may mediate the pathogenic response
to cardiovascular risk factors. Here, we tested a corollary of that hypothesis, that is, that the …

Non-alcoholic fatty liver disease (NAFLD) is a significant consequence of metabolic
dysfunction, often associated with changes in the intestinal microbiota. Prebiotics and …

The accumulation of exogenous silver nanoparticles (AgNPs) will terminally bring about liver
injury, including cell death, where DNA methylation tends to be a crucial epigenetic …

Management of chronic obesity-associated metabolic disorders is a key challenge for
biomedical researchers. During chronic obesity, visceral adipose tissue (VAT) undergoes …

Cellular physiology is critically regulated by multiple signaling nexuses, among which cell
death mechanisms play crucial roles in controlling the homeostatic landscape at the tissue …

Background Aberrant gluconeogenesis is considered among primary drivers of
hyperglycemia under insulin resistant conditions, with multiple studies pointing towards …

Psoriasis is classified as an autoimmune disorder characterized by abnormal immune
response leading to the development of chronic dermal inflammation. Most individuals have …