The CRISPR-Cas nuclease has emerged as a powerful genome-editing tool in recent years.
The CRISPR-Cas system induces double-strand breaks that can be repaired via the non …

As a new genetic engineering technology, gene editing can precisely modify the specific
gene sequence of the organism's genome. In the last 10 years, with the rapid development …

Repair of DNA double-strand breaks (DSBs) and its regulation are tightly integrated inside
cells. Homologous recombination, nonhomologous end joining and microhomology …

Genodermatoses encompass a wide range of inherited skin diseases, many of which are
monogenic. Genodermatoses range in severity and result in early-onset cancers or life …

Mercaptopyrimidine derivatives are heterocyclic compounds with potent biological activities
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …

The ability to precisely edit genomes by deleting or adding genetic information enables the
study of biological functions and the building of efficient cell factories. In many …

Nonhomologous end joining (NHEJ), one of the major DNA double‐strand break repair
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …

Background DNA double‐strand breaks (DSBs) are harmful to the cell as it could lead to
genomic instability and cell death when left unrepaired. Homologous recombination and …

Genome editing technology is widely used in the field of laboratory animal science for the
production of genetic disease models and the analysis of gene function. One of the major …

The CRISPR/Cas technology of targeted genome editing made it possible to carry out
genetic engineering manipulations with eukaryotic genomes with a high efficiency. Targeted …