The human skeleton has remarkable regenerative properties, being one of the few
structures in the body that can heal by recreating its normal cellular composition, orientation …

Bone tissue engineering is becoming an ideal strategy to replace autologous bone grafts for
surgical bone repair, but the multihierarchical complexity of natural bone is still difficult to …

The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is
regarded as a major mechanosensor in bone homeostasis. However, the role of Piezo1 in …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

Advances in bioprinting have enabled the fabrication of complex tissue constructs with high
speed and resolution. However, there remains significant structural and biological …

The dynamics of cell mechanics and epigenetic signatures direct cell behaviour and fate,
thus influencing regenerative outcomes. In recent years, the utilisation of 2D geometric (ie …

Piezo proteins are mechanically activated ion channels, which are required for
mechanosensing functions in a variety of cell types. While we and others have previously …

Orthopedic implants are widely used for the treatment of bone defects caused by injury,
infection, tumor and congenital diseases. However, poor osseointegration and implant …

The surface topography of implantable devices is of crucial importance for guiding the
cascade of events that starts from the initial contact of the cells with the surface and …

The repair of critical bone defects remains challenging worldwide. Three canonical pillars
(biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have …