The human gut harbors native microbial communities, forming a highly complex ecosystem.
Synthetic microbial communities (SynComs) of the human gut are an assembly of …

Dynamic flux balance analysis (DFBA) is an extension of classical flux balance analysis that
allows the dynamic effects of the extracellular environment on microbial metabolism to be …

Chemical engineering applications have been a source of challenging optimization
problems for over 50 years. For many chemical process systems, detailed steady state and …

At publication, The Control Handbook immediately became the definitive resource that
engineers working with modern control systems required. Among its many accolades, that …

The production of bioethanol, biohydrogen and biogas from wheat straw was investigated
within a biorefinery framework. Initially, wheat straw was hydrothermally liberated to a …

Fed-batch cultures are extensively used for the production of therapeutic proteins. However,
process optimization is hampered by lack of quantitative models of mammalian cellular …

Plant metabolism is characterized by a unique complexity on the cellular, tissue, and organ
levels. On a whole-plant scale, changing source and sink relations accompanying plant …

Dynamic flux balance analysis (DFBA) provides a platform for detailed design, control and
optimization of biochemical process technologies. It is a promising modeling framework that …

In this study, we propose a two-stage optimal control framework for a fed-batch bioreactor.
The high-level controller aims to obtain the optimal feed trajectory that maximizes the final …

Among the vast variety of Saccharomyces cerevisiae strains, the BY family is particularly
important because the widely used deletion collections are based on this background. Here …