Background One of the most malignant tumors in men is prostate cancer that is still incurable
due to its heterogenous and progressive natures. Genetic and epigenetic changes play …

Prostate cancer is one of the most commonly diagnosed cancers in men and is a major
cause of cancer-related deaths worldwide. Among the molecular processes that contribute …

Glioblastoma (GBM) constitutes the most lethal primary brain tumor for which
immunotherapy has provided limited benefit. The unique brain immune landscape is …

Cholesterol homeostasis has been implicated in the regulation of cellular and body
metabolism. Hence, deregulated cholesterol homeostasis leads to the development of many …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Urological cancers include bladder, prostate and renal cancers that can cause death in
males and females. Patients with urological cancers are mainly diagnosed at an advanced …

Enzalutamide (Enz) is a next-generation androgen receptor (AR) antagonist used to treat
castration-resistant prostate cancer (CRPC). Unfortunately, the relapsing nature of CRPC …

Considering the dismal prognosis of castration-resistant prostate cancer (CRPC), it is critical
to identify novel therapeutic targets in this disease. Malignant cells have metabolic …

Dysregulation of lipid metabolism is associated with cardiovascular/metabolic diseases,
including atherosclerosis, liver diseases and type 2 diabetes mellitus (T2DM). Several …

Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant
modification of the tumour's bioenergetics provides energy for tumour growth and …