The cyanobacterial circadian system: from biophysics to bioevolution

CH Johnson, PL Stewart, M Egli - Annual review of biophysics, 2011 - annualreviews.org
Recent studies have unveiled the molecular machinery responsible for the biological clock
in cyanobacteria and found that it exerts pervasive control over cellular processes including …

How a cyanobacterium tells time

G Dong, SS Golden - Current opinion in microbiology, 2008 - Elsevier
The cyanobacterium Synechococcus elongatus builds a circadian clock on an oscillator
composed of three proteins, KaiA, KaiB, and KaiC, which can recapitulate a circadian rhythm …

Ordered phosphorylation governs oscillation of a three-protein circadian clock

MJ Rust, JS Markson, WS Lane, DS Fisher, EK O'Shea - Science, 2007 - science.org
The simple circadian oscillator found in cyanobacteria can be reconstituted in vitro using
three proteins—KaiA, KaiB, and KaiC. The total phosphorylation level of KaiC oscillates with …

Cost and precision of Brownian clocks

AC Barato, U Seifert - Physical Review X, 2016 - APS
Brownian clocks are biomolecular networks that can count time. A paradigmatic example are
proteins that go through a cycle, thus regulating some oscillatory behavior in a living system …

Cyanobacterial circadian pacemaker: Kai protein complex dynamics in the KaiC phosphorylation cycle in vitro

H Kageyama, T Nishiwaki, M Nakajima, H Iwasaki… - Molecular cell, 2006 - cell.com
Summary KaiA, KaiB, and KaiC are essential proteins of the circadian clock in the
cyanobacterium Synechococcus elongatus PCC 7942. The phosphorylation cycle of KaiC …

Robust circadian oscillations in growing cyanobacteria require transcriptional feedback

SW Teng, S Mukherji, JR Moffitt, S De Buyl, EK O'shea - Science, 2013 - science.org
The remarkably stable circadian oscillations of single cyanobacteria enable a population of
growing cells to maintain synchrony for weeks. The cyanobacterial pacemaker is a …

An allosteric model of circadian KaiC phosphorylation

JS van Zon, DK Lubensky… - Proceedings of the …, 2007 - National Acad Sciences
In a recent series of ground-breaking experiments, Nakajima et al.[Nakajima M, Imai K, Ito H,
Nishiwaki T, Murayama Y, Iwasaki H, Oyama T, Kondo T (2005) Science 308: 414–415] …

The day/night switch in KaiC, a central oscillator component of the circadian clock of cyanobacteria

YI Kim, G Dong, CW Carruthers Jr… - Proceedings of the …, 2008 - National Acad Sciences
The circadian oscillator of the cyanobacterium Synechococcus elongatus is composed of
only three proteins, KaiA, KaiB, and KaiC, which, together with ATP, can generate a self …

The energy cost and optimal design for synchronization of coupled molecular oscillators

D Zhang, Y Cao, Q Ouyang, Y Tu - Nature physics, 2020 - nature.com
A model of coupled molecular biochemical oscillators is proposed to study non-equilibrium
thermodynamics of synchronization. Under general considerations, we find that chemical …

Dual KaiC-based oscillations constitute the circadian system of cyanobacteria

Y Kitayama, T Nishiwaki, K Terauchi… - Genes & …, 2008 - genesdev.cshlp.org
In the cyanobacterium Synechococcus elongatus PCC 7942, the KaiA, KaiB, and KaiC
proteins are essential for the generation of circadian rhythms. Both in vivo and in vitro …