Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

In this review we propose that there are sex differences in how men and women enter onto
the path that can lead to addiction. Males are more likely than females to engage in risky …

Of the many conceptual distinctions present in psychology today, the approach-avoidance
distinction stands out as one of, if not the, most fundamental and basic. The distinction …

This review highlights recent evidence from clinical and basic science studies supporting a
role for estrogen in neuroprotection. Accumulated clinical evidence suggests that estrogen …

Leptin's effects are mediated by interactions with a receptor that is alternatively spliced,
resulting in at least five different murine forms: Ob-Ra, Ob-Rb, Ob-Rc, Ob-Rd, and Ob-Re. A …

There are 3 common physiological estrogens, of which estradiol (E2) is seen to decline
rapidly over the menopausal transition. This decline in E2 has been associated with a …

Research in basic neuroscience has provided biological plausibility for the hypothesis that
estrogen replacement therapy (ERT) would protect against cognitive aging in healthy …

Estradiol protects against brain injury, neurodegeneration, and cognitive decline. Our
previous work demonstrates that physiological levels of estradiol protect against stroke …

Estrogens have direct effects on the brain areas controlling cognition. One of the most
studied of these regions is the dorsal hippocampal formation, which governs the formation of …

Pharmacological and biochemical approaches were used to elucidate the involvement of
growth factor signaling pathways mediating estrogen neuroprotection in primary cortical …