In primary Sjögren syndrome (pSS), the function of the salivary glands is often considerably
reduced. Multiple innate immune pathways are likely dysregulated in the salivary gland …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

There is mounting evidence that the microbiome has potent immunoregulatory functions. We
assessed the effects of intestinal dysbiosis in a model of Sjögren syndrome (SS) by …

Objectives To explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-
helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) and B-cell mucosa …

Objective To develop ultrasound (US) definitions and a US novel scoring system for major
salivary gland (SG) lesions in patients with primary Sjögren's syndrome (pSS) and to test …

Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …

Background The objective of this study was to characterize the clinicopathologic features of
sicca syndrome associated with immune checkpoint inhibitor (ICI) therapy. Subjects …

Tertiary lymphoid structures (TLS) are frequently observed in target organs of autoimmune
diseases. TLS present features of secondary lymphoid organs such as segregated T and B …

Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by progressive
inflammation and tissue damage in salivary glands and lacrimal glands. Our previous …