Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Mucin type O‐glycosylation is one of the most diverse types of glycosylation, playing
essential roles in tissue development and homeostasis. In complex organisms, O‐GalNAc …

Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble
polarity complexes function to specify and maintain apical and basolateral membrane …

Background While the underlying causes of cancer are genetic modifications, changes in
cellular states mediate cancer development. Tumor cells display markedly changed …

Apico-basal polarity is typical of cells present in differentiated epithelium while front-rear
polarity develops in motile cells. In cancer development, the transition from epithelial to …

Background Complex diseases such as cancer are a consequence of numerous causes.
State of the art personalised medicine approaches are mostly based on evaluating patients' …

Introduction: Pancreatic cancer (PC) is characterized by mucin overexpression. MUC4 is the
most differentially overexpressed membrane-bound mucin that plays a functional role in …

A major branch of glycobiology and glycan-focused biomedicine studies the interaction
between carbohydrates and other biopolymers, most importantly, glycan-binding proteins …

Simple Summary Early cancer detection is a challenge in treating cancer patients.
Remarkably, carcinomas of the breast, lung, liver, pancreas, ovary, and colon contribute to …

Aberrant expression of O-glycans is a hallmark of epithelial cancers. Mucin-type O-
glycosylation is initiated by a large family of UDP-GalNAc: polypeptide N …