Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer
progression, these mechanisms are manipulated to become harmful. O-glycosylation, a …

Tumor therapeutic resistances are frequently linked to the recurrence and poor prognosis of
cancers and have been a key bottleneck in clinical tumor treatment. Mucin1 (MUC1), a …

Mucin1 (MUC1) is abnormally glycosylated and overexpressed in a variety of epithelial
cancers and plays a critical role in tumor progression. MUC1 has received remark attention …

GT-00AxIL15 is a novel interleukin-15-based immunocytokine targeting a tumor-specific,
glycosylated epitope of MUC1 (TA-MUC1). We characterized mode of action …

Background: Colorectal cancer represents a common malignancy and remains incurable in
the metastatic stage. Identification of molecular alterations that are present in colorectal …

Objective Glioblastoma (GBM) is one of the most aggressive brain tumors and often leads to
poor outcomes. Studies have indicated that glycan levels are significantly correlated with the …

Advanced non-small cell lung cancer (NSCLC) is a severe disease and still has high
mortality rate after conventional treatment (eg, surgical resection, chemotherapy …

目的: 构建含DF3/MUC1 启动子转录调控序列和绿色荧光蛋白(green fluorescent protein, GFP)
的重组腺病毒(Ad-DF3-copGFP), 探讨其在循环肿瘤细胞(circulating tumor cell, CTC) …