Drug screening with genetically encoded fluorescent sensors: Today and tomorrow
ES Potekhina, DY Bass, IV Kelmanson… - International Journal of …, 2020 - mdpi.com
Genetically-encoded fluorescent sensors have been actively developed over the last few
decades and used in live imaging and drug screening. Real-time monitoring of drug action …
decades and used in live imaging and drug screening. Real-time monitoring of drug action …
Ion channels and relevant drug screening approaches
JG McGivern, M Ding - SLAS DISCOVERY: Advancing the …, 2020 - journals.sagepub.com
414 SLAS Discovery 25 (5) nonconducting state. However, in response to an activating
stimulus (eg, the binding of a neurotransmitter or a change in either membrane potential …
stimulus (eg, the binding of a neurotransmitter or a change in either membrane potential …
Highly parallelized, multicolor optogenetic recordings of cellular activity for therapeutic discovery applications in ion channels and disease-associated excitable cells
GB Borja, H Zhang, BN Harwood, J Jacques… - Frontiers in Molecular …, 2022 - frontiersin.org
Optogenetic assays provide a flexible, scalable, and information rich approach to probe
compound effects for ion channel drug targets in both heterologous expression systems and …
compound effects for ion channel drug targets in both heterologous expression systems and …
Advancing ion channel research with automated patch clamp (APC) electrophysiology platforms
Since its development on the cusp of the new millennium, automated patch clamp (APC)
technology has matured over the last two decades. The increased throughput it afforded …
technology has matured over the last two decades. The increased throughput it afforded …
Classification of advanced methods for evaluating neurotoxicity
Purpose of review As fields such as neurotoxicity evaluation and neuro-related drug
research are increasing in popularity, there is a demand for the expansion of neurotoxicity …
research are increasing in popularity, there is a demand for the expansion of neurotoxicity …
Parallel All-Optical Assay to Study Use-Dependent Functioning of Voltage-Gated Ion Channels in a Miniaturized Format
V Agus, TA Flak, P Picardi, S Pizzi… - … the Science of Drug …, 2021 - journals.sagepub.com
Voltage-gated ion channels produce rapid transmembrane currents responsible for action
potential generation and propagation at the neuronal, muscular, and cardiac levels. They …
potential generation and propagation at the neuronal, muscular, and cardiac levels. They …