Prevention of common diseases of the pancreas or interception of their progression is as
attractive in theory as it is elusive in practice. The fundamental challenge has been an …

Dysfunctional visceral fat plays a key role in the initiation and maintenance of chronic
inflammation, liver steatosis and subsequent systemic insulin resistance that primes the …

Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to
hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly …

Introduction Ectopic fat deposition is well appreciated as a key contributor to digestive and
liver diseases. Bile acids have emerged as pleiotropic signalling molecules involved in …

Background Maternal prepregnancy obesity is an important risk factor for offspring obesity,
which may partially operate through prenatal programming mechanisms. Objectives The …

Untargeted metabolomics of blood samples has become widely applied to study metabolic
alterations underpinning disease and to identify biomarkers. However, understanding the …

Consuming a “modern” Western diet and overnutrition may increase insulin secretion.
Additionally, nutrition-mediated hyperinsulinemia is a major driver of ectopic fat deposition …

Biological samples of lipids and metabolites degrade after extensive years in− 80 C storage.
We aimed to determine if associated multivariate models are also impacted. Prior TOFI_Asia …

Ectopic lipid accumulation, including intra-pancreatic fat deposition (IPFD), exacerbates type
2 diabetes risk in susceptible individuals. Dysregulated circulating microRNAs (miRNAs) …

High‐fat diet (HFD)‐fed mice have been widely used in the clinical investigation of obesity.
However, the long‐term effect of HFD on gut microbiota and metabolites, plasma and liver …