Superoxide ion (O2•–) is of great significance as a radical species implicated in diverse
chemical and biological systems. However, the chemistry knowledge of O2•–is rather …

Oxidative stress is a well-established cause of male infertility, with reactive oxygen species
(ROS) impairing sperm production, motility, membrane, and DNA integrity. Currently, most …

For the past 30 years strategies for the preclinical discovery and development of potential
anticancer agents have been based largely upon the testing of agents in mice bearing …

Abstract Immunostimulant preparations Macrogard®, Candida utilis, Saccharomyces
cerevisiae, Evetsel®, Chitosan®, or FinnStim® were mixed into semipurified diets and fed to …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a
protein homologous to the brown fat uncoupling protein Ucp1 (refs 1–3). As Ucp2 is widely …

Abstract The tetrazolium dye, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide
(MTT), is reduced by live but not dead cells, and this reaction is used as the end point in a …

Superoxide and its derivatives are increasingly implicated in the regulation of physiological
functions from oxygen sensing and blood pressure regulation to lymphocyte activation and …

Conventionally, a semi‐quantitative microscopic nitroblue tetrazolium (NBT) assay is used to
determine the production of superoxide anion (O2−) in various phagocytic cells. This …

Previous studies have shown that recombinant interferon gamma (IFN-gamma), crude T cell
supernatants, or appropriate T-cell lines can cause total inhibition of the growth of M …