Galectins at a glance

L Johannes, R Jacob, H Leffler - Journal of cell science, 2018 - journals.biologists.com
Galectins are carbohydrate-binding proteins that are involved in many physiological
functions, such as inflammation, immune responses, cell migration, autophagy and …

[HTML][HTML] Galectin-3 activation and inhibition in heart failure and cardiovascular disease: an update

N Suthahar, WC Meijers, HHW Silljé, JE Ho, FT Liu… - Theranostics, 2018 - ncbi.nlm.nih.gov
Galectin-3 is a versatile protein orchestrating several physiological and pathophysiological
processes in the human body. In the last decade, considerable interest in galectin-3 has …

Galectin-3: an open-ended story

J Dumic, S Dabelic, M Flögel - … et Biophysica Acta (BBA)-General Subjects, 2006 - Elsevier
Galectins, an ancient lectin family, are characterized by specific binding of β-galactosides
through evolutionary conserved sequence elements of carbohydrate-recognition domain …

Intracellular functions of galectins

FT Liu, RJ Patterson, JL Wang - … et Biophysica Acta (BBA)-General Subjects, 2002 - Elsevier
Many galectin family members are detected primarily intracellularly in most of the systems
studied, although certain members can be found both inside and outside of cells. Specific …

Galectin-3–a jack-of-all-trades in cancer

AU Newlaczyl, LG Yu - Cancer letters, 2011 - Elsevier
Galectin-3 is a mammalian β-galactoside-binding protein that is expressed by various types
of human cells. Changes in galectin-3 expression and subcellular and intercellular …

Galectins and immune responses—just how do they do those things they do?

S Thiemann, LG Baum - Annual review of immunology, 2016 - annualreviews.org
Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …

Galectinomics: finding themes in complexity

DNW Cooper - Biochimica et Biophysica Acta (BBA)-General Subjects, 2002 - Elsevier
With the rapid explosion of genomic sequence databases, there has been an equivalent
boom in genomics, the use of sequence information to define and compare gene families …

Secretion of the galectin family of mammalian carbohydrate-binding proteins

RC Hughes - Biochimica et Biophysica Acta (BBA)-General Subjects, 1999 - Elsevier
Galectins are cytosolic proteins that lack any signal sequence for transport into the
endoplasmic reticulum and are not glycosylated, although several galectins contain …

[HTML][HTML] Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes

N Ahmad, HJ Gabius, S André, H Kaltner… - Journal of Biological …, 2004 - ASBMB
Galectin-3 is unique among the galectin family of animal lectins in its biological activities and
structure. Most members of the galectin family including galectin-1 possess apoptotic …

On the role of galectin-3 in cancer apoptosis

S Nakahara, N Oka, A Raz - Apoptosis, 2005 - Springer
Galectin-3, a member of the β-galactoside-binding gene family, is a multifunctional protein
implicated in a variety of biological functions, including tumor cell adhesion, proliferation …