Single-cell multi-omics technologies and methods characterize cell states and activities by
simultaneously integrating various single-modality omics methods that profile the …

Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

Abstract Three-dimensional (3D) cell culture technologies, such as organoids, are
physiologically relevant models for basic and clinical applications. Automated microfluidics …

Existing methods for RNA diagnostics, such as reverse transcription PCR (RT-PCR), mainly
rely on nucleic acid amplification (NAA) and RT processes, which are known to introduce …

High-throughput single-cell RNA sequencing has transformed our understanding of complex
cell populations, but it does not provide phenotypic information such as cell-surface protein …

Many biological systems are composed of diverse single cells. This diversity necessitates
functional and molecular single-cell analysis. Single-cell protein analysis has long relied on …

Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

Extracellular vesicles (EVs) are complex lipid membrane vehicles with variable expressions
of molecular cargo, composed of diverse subpopulations that participate in the intercellular …

Single-cell genomics has now made it possible to create a comprehensive atlas of human
cells. At the same time, it has reopened definitions of a cell's identity and of the ways in …

The inability to make broad, minimally biased measurements of a cell's proteome stands as
a major bottleneck for understanding how gene expression translates into cellular …