Present therapeutic approaches do not effectively target metastatic cancers, often limited by
their inability to eliminate already-seeded non-proliferative, growth-arrested, or therapy …

Tumor-derived exosomes play a multifaceted role in preparing the pre-metastatic niche,
promoting cancer dissemination, and regulating cancer cell dormancy. A brief review of …

Exosomes play important roles in cancer progression. Although its contents (eg, proteins
and microRNAs) have been focused on in cancer research, particularly as potential …

Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells
(DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor …

Metastatic recurrence is a major hurdle to overcome for successful control of cancer-
associated death. Residual tumor cells in the primary site, or disseminated tumor cells in …

Human aging is an inevitable and complex phenomenon characterized by a progressive,
gradual degradation of physiological and cellular processes that leads from vulnerability to …

Researchers have developed several three-dimensional (3D) culture systems, including
spheroids, organoids, and tumoroids with increased properties of cancer stem cells (CSCs) …

Background The tumor microenvironment significantly influences breast cancer
development, progression, and metastasis. Various immune cell populations, including T …

Dormant, disseminated breast cancer cells resist treatment and may relapse into malignant
metastases after decades of quiescence. Identifying how and why these dormant breast …

Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and
reside in a dormant state within the mesenchymal stem cell niche. Research has focussed …