Catalysis has a central role in organic synthetic methodology, especially in stereoselective
reactions. In many reactions, enantioselectivity is made possible through the use of chiral …

This review analyzes a development in biochemistry, enzymology and biotechnology that
originally came as a surprise. Following the establishment of directed evolution of …

DNA aptamers have emerged as novel molecular tools in disease theranostics owing to
their high binding affinity and specificity for protein targets, which rely on their ability to fold …

Allosteric mechanisms are commonly employed regulatory tools used by proteins to
orchestrate complex biochemical processes and control communications in cells. The …

Synthetic biology aims at designing new biological functions from first principles. These new
designs allow to expand the natural solution space and overcome the limitations of naturally …

Biocatalysts that are eco-friendly, sustainable, and highly specific have great potential for
applications in the production of fine chemicals, food, detergents, biofuels, pharmaceuticals …

Enzymes offer a more environmentally friendly and low-impact solution to conventional
chemistry, but they often require additional engineering for their application in industrial …

Directed evolution has transformed protein engineering offering a path to rapid improvement
of protein properties. Yet, in practice it is limited by the hyper-astronomic protein sequence …

Over the last 40 years nuclear magnetic resonance (NMR) spectroscopy has established
itself as one of the most versatile techniques for the characterization of biomolecules …

Enzymes catalyze the chemical reactions of life. For nearly half of known enzymes, catalysis
requires the binding of small molecules known as cofactors. Polypeptide-cofactor complexes …