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Tuberculosis (TB) remains an impactful infectious disease, leading to millions of deaths
every year. Mycobacterium tuberculosis causes the formation of granulomas, which will …

Confirmatory diagnosis of childhood tuberculosis (TB) remains a challenge mainly due to its
dependence on sputum samples and the paucibacillary nature of the disease. Thus, only …

The diagnosis of pediatric tuberculosis (TB) poses a challenge for clinical teams worldwide.
TB-mediated changes in the expression of host genes in the peripheral blood can serve as …

Each year, an estimated 1· 2 million incident cases of tuberculosis occur in children younger
than 15 years globally, and approximately a quarter of these children will die from …

The emergence of next-generation sequencing technologies and computational advances
have expanded our understanding of gene expression regulation (ie, the transcriptome) …

Background An accurate, rapid, non-sputum-based triage test for diagnosing tuberculosis
(TB) is needed. Methods A prospective evaluation of the Cepheid GeneXpert …

Background The diagnostic gaps for childhood tuberculosis (TB) remain considerable in
settings with high TB incidence and resource constraints. We established and evaluated the …

Sputum induction (SI) is a non-invasive technique to obtain lower airway samples from
people who do not spontaneously produce sputum. Since its introduction in 1958, its use …

My PhD thesis focuses on the neglected field of TBM in one of the most vulnerable
populations. It includes a literature review, a report on an interventional clinical trial from …